Buffalo Wild Wings All-American Cheeseburger
This cheeseburger is high because of the tomato, pickles, and mayo, with mustard adding a moderate note.
Most of this is cooked to order, which is the best case for histamine. Even so, a restaurant kitchen preps ahead and holds things warm through a service, so freshness varies more than it would at home. The rating above comes from the chain's published ingredients. If a dish is borderline for you, asking how it is prepared tells you more than the menu does.
Yes, the All-American Cheeseburger at Buffalo Wild Wings is high for histamine intolerance. The beef is not the issue: the standard tomato, pickles, mayo, and challah bun are all high-histamine items, and they come built into the burger.
Why buffalo wild wings all-american cheeseburger is rated high
This burger surprises people because the part they worry about, the meat, is not what earned the rating. The two patties and the shredded lettuce are not the drivers. What pushes it high is everything around them. Tomato is a classic histamine liberator, meaning it can prompt your body to release histamine it was already storing rather than delivering much of its own, which is why a fresh red slice still counts. Pickles and mayo are two of the most consistently high items on histamine intolerance lists, and the challah bun rates high here as well. On top of that, the american cheese, as a processed cheese, and the sweet mustard each sit at moderate. Four high components plus two moderate ones is how a plain-looking cheeseburger ends up where it does.
What changes your risk
- The toppings carry it, not the beef — tomato, pickles, mayo, and the challah bun are the four high components. The patties and shredded lettuce are not what put this burger high.
- Tomato works differently from the rest — the pickles and mayo bring their own histamine load, while the tomato tends to prompt your body to release histamine it was already holding. Same result on the plate, different route.
- The moderates stack on top — american cheese counts as processed cheese and the mustard is a sweet mustard, both at moderate. They do not decide the rating, but they add to it.
- It arrives fully assembled — every component is layered into one item before it reaches the table, so there is no part of it that sits lower than the rest.
- Warm holding is a real question for this one — a cooked beef and cheese item is protein-rich, so how long an assembled burger sits at the pass before it is run out can matter, depending on how it is held.
Lower-histamine alternatives
Buffalo Wild Wings lists Grilled Chicken Breast as the lower-rated protein, which is the closest thing to a straight swap for the burger. French Fries and Tots sit lower on the side, and Beef Tallow, Salt & Pepper Dry Rub, Everything Seasoning, and Tortilla Chip Salt are the lower-rated flavorings if you want something seasoned rather than sauced. There is no lower version of this burger itself, since the high components are the recipe.
How to lower the risk
Buffalo Wild Wings publishes what is in a menu item rather than what can be left off, so there is no verified lighter build of this burger to point you to. The reliable plan is to order from the lower-rated items instead: Grilled Chicken Breast with French Fries or Tots, seasoned with the Salt & Pepper Dry Rub or Everything Seasoning, keeps the plate in much better territory than a modified burger would. It also helps to skip dips and sauces served alongside, since a cup of dressing can outweigh everything else on the plate. If you are sharing a table, ask for your own plate rather than picking from a shared basket where sauced items and burger toppings mix in.
Common questions
Is the beef patty itself high in histamine?
The patties are not among the drivers for this item. The rating comes from the tomato, pickles, mayo, and challah bun that come standard on it.
Can I just order it without the tomato and pickles?
Buffalo Wild Wings publishes what is in an item, not what can be removed, so there is no verified version of this burger without them. Their lower-rated items are the dependable route.
Why is fresh tomato a problem if it is not fermented?
Tomato is a histamine liberator. It can trigger the body to release its own stored histamine, so it gets flagged even when the slice is perfectly fresh.
Is american cheese as bad as aged cheese for histamine?
It rates as processed cheese at moderate here, so it is not the top driver on this burger. It still adds to the total alongside the tomato, pickles, mayo, and bun.
This rating comes from Buffalo Wild Wings' own published ingredient statement, read on August 11, 2026. Restaurant recipes vary by location and change over time, so always check the current listing: source 1, source 2. How we rate foods →
Buffalo Wild Wings All-American Cheeseburger and Buffalo Wild Wings are trademarks of their respective owners. This page is an independent histamine reference and is not affiliated with, endorsed by, or sponsored by the brand.
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For educational purposes only. Not medical advice. Consult a healthcare professional for personal guidance.
References
- SIGHI Food Compatibility List — SIGHI (2026)
- Histamine and histamine intolerance — Maintz & Novak (2007)
- Histamine Intolerance: The Current State of the Art — Comas-Basté et al. (2020)
- Low-Histamine Diets: Is the Exclusion of Foods Justified by Their Histamine Content? — Sánchez-Pérez et al. (2021)
- Histamine Intolerance: Symptoms, Diagnosis, and Beyond — Jochum (2024)
- Guideline on management of suspected adverse reactions to ingested histamine — Reese et al. (2021)