Papa Murphy's Buffalo Sauce
This buffalo sauce is high in histamine, mainly from the aged cayenne peppers and vinegar.
This is sold raw and you bake it at home, which is the freshest case on this whole list. Nothing sits in a warmer, and you control how long it waits between the shop and the oven. Refrigerate it as soon as you get home and bake it the same day, because histamine builds up as protein foods sit whether that happens in a kitchen or in your fridge.
Yes, Papa Murphy's Buffalo Sauce is high in histamine. It is built on aged cayenne red peppers and distilled vinegar, and the aging the peppers go through before they become sauce is where the histamine comes from.
Why papa murphy's buffalo sauce is rated high
This is a tangy hot sauce made from distilled vinegar, aged cayenne red peppers, salt, water, modified corn starch, canola oil, paprika, xanthan gum, and garlic powder. The peppers are not used fresh off the plant. They are held in salt for a long stretch first, and during that aging bacteria work on the pepper mash, which is exactly the situation where histamine tends to build. A fresh cayenne pepper is a different food from an aged one, and it is the aging step that moves this from a fresh chili to a high-histamine hot sauce. The distilled vinegar base is another thing most people with histamine intolerance are told to skip, and paprika runs moderate on its own. Put together, the sauce is high before it ever touches a pizza.
What changes your risk
- The aged peppers carry it — the histamine here traces to the peppers being aged in salt before they are made into sauce, not to the heat or the tang. Freshly picked cayenne is a different story from cayenne that has sat and fermented.
- The vinegar base adds on — distilled vinegar is on most histamine-intolerance avoid lists, so the liquid the peppers sit in is contributing rather than diluting.
- Paprika lifts it further — paprika is moderate on its own, so it nudges the sauce up instead of softening it.
- Sitting at the counter does not lower it — this sauce is already a preserved, aged product. Time at the build station cannot bring it back down, and an already-fermented product held at room temperature for a long stretch can drift higher depending on how it is kept.
- Baking at home will not remove it — Papa Murphy's pizzas are baked by you at home, and heat does not undo histamine that formed while the peppers were aging. A hotter oven or a longer bake changes nothing about this.
Lower-histamine alternatives
There is no fresher or milder version of this sauce to swap in, because the aging is the whole point of how it is made. The lower-histamine items to look at here are Chicken, Onion Mix, and Zesty Herb Blend. Those are the ones worth building around if you want the pizza to land lower.
How to lower the risk
Papa Murphy's is a build-to-order counter, so what you can actually control is which components go on. Buffalo Sauce is one of the higher things you could put on a pizza here, and there is no way to make the version in front of you lower. If you are ordering, the useful choice is to build with the lower items instead: Chicken, Onion Mix, and Zesty Herb Blend. Since you take the pizza home and bake it yourself, getting it into the oven rather than leaving it on the counter for hours is good handling generally, though it will not change the sauce's level.
Common questions
Why is buffalo sauce high in histamine when peppers are low?
Fresh peppers and aged peppers are not the same food. The cayenne red peppers in this sauce are aged before they become sauce, and that aging period is when bacteria can build histamine in the pepper mash.
Does the vinegar in buffalo sauce cause the histamine?
Vinegar is not what creates the histamine, but distilled vinegar is on most histamine-intolerance avoid lists, so it adds to the concern here. The aged cayenne peppers are the bigger driver.
Is a milder hot sauce lower in histamine?
Heat level and histamine are not the same thing. A sauce's histamine tracks how the peppers were processed, so a mild sauce made from aged peppers can still run high.
Will baking the pizza cook off the histamine in the buffalo sauce?
No. Baking does not remove histamine that has already formed. The oven changes the texture and the taste, not the level.
This rating comes from Papa Murphy's own published ingredient statement, read on August 10, 2026. Restaurant recipes vary by location and change over time, so always check the current listing: source 1, source 2. How we rate foods →
Papa Murphy's Buffalo Sauce and Papa Murphy's are trademarks of their respective owners. This page is an independent histamine reference and is not affiliated with, endorsed by, or sponsored by the brand.
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For educational purposes only. Not medical advice. Consult a healthcare professional for personal guidance.
References
- SIGHI Food Compatibility List — SIGHI (2026)
- Histamine and histamine intolerance — Maintz & Novak (2007)
- Histamine Intolerance: The Current State of the Art — Comas-Basté et al. (2020)
- Low-Histamine Diets: Is the Exclusion of Foods Justified by Their Histamine Content? — Sánchez-Pérez et al. (2021)
- Histamine Intolerance: Symptoms, Diagnosis, and Beyond — Jochum (2024)
- Guideline on management of suspected adverse reactions to ingested histamine — Reese et al. (2021)