Papa Murphy's Meatballs
These meatballs are high in histamine, driven by textured soy protein concentrate and romano cheese.
This is sold raw and you bake it at home, which is the freshest case on this whole list. Nothing sits in a warmer, and you control how long it waits between the shop and the oven. Refrigerate it as soon as you get home and bake it the same day, because histamine builds up as protein foods sit whether that happens in a kitchen or in your fridge.
Papa Murphy's Meatballs are high in histamine. Two ingredients in the mix do it: romano cheese, which is an aged hard cheese, and textured soy protein concentrate, a heavily processed soy ingredient that sits high on histamine intolerance lists.
Why papa murphy's meatballs are rated high
This topping is beef, water, textured soy protein concentrate, eggs, romano cheese, salt, and spices. The beef and the eggs are not what pushes it up. Romano is aged for months, and aging is the classic route to histamine in cheese, so by the time it is worked into the meatball mix it is already high. Textured soy protein concentrate is the other driver, a processed soy ingredient that lands high on the lists most people with histamine intolerance work from. Meatballs as a category already sit at moderate because they are a ground, pre made, mixed protein, and these two ingredients take the topping the rest of the way up.
What changes your risk
- Romano is aged, and that is where its histamine came from — it was never fresh cheese in this mix, and nothing at the store or in your oven undoes months of aging.
- Textured soy protein concentrate is the other half — it is mixed through the meatballs rather than sprinkled on, so it is in every portion of the topping.
- These arrive pre made — the meatballs come to the store already combined with the romano and the soy protein, so the counter is not where any of this gets decided.
- How long the topping sits at the prep counter — this is a protein rich mix, so cold holding is what keeps storage bacteria in check. Time spent warm is the one variable that can add to what is already there.
- Baking at home does not lower it — your oven kills bacteria but does not remove histamine that formed while the cheese was aging.
Lower-histamine alternatives
Chicken is the one to know about here. It is on Papa Murphy's lower rated list and it is a fresh, unaged protein rather than a pre mixed one, which is exactly the difference that matters between these two toppings. Onion Mix and Zesty Herb Blend are the other lower rated options, so if you want flavor without the aged cheese, those are the pieces to build with.
How to lower the risk
Papa Murphy's is a build your own counter, so the useful move is at the topping stage rather than after. Choosing Chicken instead of the Meatballs skips both drivers at once, since Chicken carries neither the aged romano nor the textured soy protein concentrate. Onion Mix and Zesty Herb Blend are lower rated as well and give you something to build flavor with. Once the meatballs are on the pizza there is nothing you can do at home to bring them down, so this is a decision made at the counter.
Common questions
Are meatballs high in histamine?
Meatballs as a category sit at moderate, since they are ground and pre mixed. Papa Murphy's version is high because the mix also contains romano cheese and textured soy protein concentrate.
Is romano cheese as high in histamine as parmesan?
Yes, they are treated the same way on histamine lists. Both are hard cheeses aged for months, and that aging is what builds the histamine.
Does the soy in these meatballs matter if I tolerate soy fine?
Tolerating soy generally is a different question from histamine. Textured soy protein concentrate is rated high here regardless of whether soy itself sits well with you, so it still counts toward the load.
Which Papa Murphy's topping is lower in histamine?
Chicken is the lower rated protein topping, and Onion Mix and Zesty Herb Blend are the other lower rated options on their list.
This rating comes from Papa Murphy's own published ingredient statement, read on August 10, 2026. Restaurant recipes vary by location and change over time, so always check the current listing: source 1, source 2. How we rate foods →
Papa Murphy's Meatballs and Papa Murphy's are trademarks of their respective owners. This page is an independent histamine reference and is not affiliated with, endorsed by, or sponsored by the brand.
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For educational purposes only. Not medical advice. Consult a healthcare professional for personal guidance.
References
- SIGHI Food Compatibility List — SIGHI (2026)
- Histamine and histamine intolerance — Maintz & Novak (2007)
- Histamine Intolerance: The Current State of the Art — Comas-Basté et al. (2020)
- Low-Histamine Diets: Is the Exclusion of Foods Justified by Their Histamine Content? — Sánchez-Pérez et al. (2021)
- Histamine Intolerance: Symptoms, Diagnosis, and Beyond — Jochum (2024)
- Guideline on management of suspected adverse reactions to ingested histamine — Reese et al. (2021)