Buffalo Wild Wings American Cheese
This American cheese is high in histamine, mainly because of the soy it contains.
Most of this is cooked to order, which is the best case for histamine. Even so, a restaurant kitchen preps ahead and holds things warm through a service, so freshness varies more than it would at home. The rating above comes from the chain's published ingredients. If a dish is borderline for you, asking how it is prepared tells you more than the menu does.
Yes. Buffalo Wild Wings American Cheese is rated high for histamine intolerance, driven mainly by the soy it contains, with the processed cheese base adding on top of that. It also carries a histamine liberator tag, which means it can set off symptoms even though the milk and cream in it are fresh dairy.
Why buffalo wild wings american cheese is rated high
The confusing part is that nothing in this slice is aged the way a sharp cheddar or a blue cheese is. It is a meltable processed slice built from milk and cream, held together with salt, sodium citrate, lecithin, sorbic acid and citric acid, plus soy. What lifts it is that soy, which sits high on histamine lists, layered on the fact that this is a processed cheese rather than a fresh one. A liberator works differently from a food that is loaded with histamine: instead of delivering a big load, it can nudge your body into releasing histamine it was already holding. That is why someone who does fine with plain fresh dairy can still feel this slice, and why the reaction can seem out of proportion to how little cheese was involved.
What changes your risk
- Soy is the driver — the soy is what pushes this slice to high, and it is blended into the cheese itself rather than added at the counter.
- Processed, not fresh — american cheese is scored moderate as a processed cheese on its own. Stacked with the soy, that combination is what lands the slice at high.
- The dairy base is the mild part — the milk and cream here are fresh dairy, not cultured or aged, so they are not the reason for the rating.
- How much is in the order — a liberator effect tends to track with how much you actually eat, so an item carrying a lot of this cheese asks more of you than one carrying a little.
- Time on a warm line — melted cheese is a protein rich dairy food, so slices that sit warm for a long stretch before reaching you have been handled less ideally than ones pulled straight into a hot order.
Lower-histamine alternatives
If you are building an order at Buffalo Wild Wings that skips this cheese, the items the index rates lower are Grilled Chicken Breast, French Fries, Tots, Tortilla Chips, Tortilla Chip Salt, Beef Tallow, Everything Seasoning and the Salt & Pepper Dry Rub. Grilled Chicken Breast with the Salt & Pepper Dry Rub is the closest thing here to a real meal that leaves the cheese out entirely, and Tortilla Chips with Tortilla Chip Salt covers the shared table plate.
How to lower the risk
Buffalo Wild Wings publishes what goes into this cheese, not a way to change it, and nothing in it is listed as removable, so the only real lever is whether you order an item that carries it. If a menu item lists american cheese, assume the soy comes along with it. Building the order around Grilled Chicken Breast with a dry seasoning keeps you inside the lower rated items. And because this one is tagged as a liberator, it tends to show up worst on a day when the rest of what you have eaten is already on the high side.
Common questions
Why is American cheese high in histamine if it is not aged?
Aging is not the only route to a high rating. Here the soy in the slice is the main driver, and processed cheese scores above fresh dairy on its own, so the level comes from what it is made with rather than from time spent ripening.
What does it mean that this cheese is a histamine liberator?
It means the slice can prompt your body to release histamine it was already storing, rather than only adding histamine of its own. That is why a small amount can produce a reaction that feels bigger than the portion suggests.
Does melting the cheese lower the histamine?
No. Heat does not remove histamine that is already present, and it does nothing about the soy content either, so a melted slice and a cold one carry the same rating.
Is plain milk lower than this cheese?
Fresh dairy like the milk and cream in this slice generally sits lower than processed or cultured cheese. That does not rescue this product, though, because the soy is what drives its rating.
This rating comes from Buffalo Wild Wings' own published ingredient statement, read on August 11, 2026. Restaurant recipes vary by location and change over time, so always check the current listing: source 1, source 2. How we rate foods →
Buffalo Wild Wings American Cheese and Buffalo Wild Wings are trademarks of their respective owners. This page is an independent histamine reference and is not affiliated with, endorsed by, or sponsored by the brand.
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For educational purposes only. Not medical advice. Consult a healthcare professional for personal guidance.
References
- SIGHI Food Compatibility List — SIGHI (2026)
- Histamine and histamine intolerance — Maintz & Novak (2007)
- Histamine Intolerance: The Current State of the Art — Comas-Basté et al. (2020)
- Low-Histamine Diets: Is the Exclusion of Foods Justified by Their Histamine Content? — Sánchez-Pérez et al. (2021)
- Histamine Intolerance: Symptoms, Diagnosis, and Beyond — Jochum (2024)
- Guideline on management of suspected adverse reactions to ingested histamine — Reese et al. (2021)