Papa Murphy's Garlic Knots
These garlic knots are moderate, from the wheat flour, yeast, and soybean oil in the dough.
This is sold raw and you bake it at home, which is the freshest case on this whole list. Nothing sits in a warmer, and you control how long it waits between the shop and the oven. Refrigerate it as soon as you get home and bake it the same day, because histamine builds up as protein foods sit whether that happens in a kitchen or in your fridge.
Papa Murphy's Garlic Knots come in at moderate. It is a plain baked dough, and the three things that put it in the middle are the wheat flour, the yeast that raises it, and the soybean oil worked into it.
Why papa murphy's garlic knots are rated moderate
There is nothing dramatic in these knots. The ingredient list is wheat flour, water, sugar, yeast, salt, soybean oil, cultured corn syrup, and garlic. What lands it at moderate is a stack of three middle-of-the-road components rather than one big one: wheat flour reads moderate, yeast used for leavening reads moderate, and soybean oil reads moderate. Put all three in the same small piece of bread and the whole thing settles at moderate. Worth saying plainly: the garlic is not the reason. Garlic is generally low in histamine, and while some people simply do not feel well after it, that is individual intolerance rather than a histamine mechanism. And because this is a dough, not a protein food, it is not the kind of thing that builds histamine while it waits around.
What changes your risk
- Three moderates in one bite — the wheat flour, the yeast, and the soybean oil each land at moderate on their own, and here they arrive together in a single small piece of bread.
- Yeast is doing real work — this is a leavened dough, so the yeast is not a trace ingredient. It is part of what the knot is.
- Portion is the honest lever — knots come as a batch, and it is easy to eat several without noticing. One knot and five knots are meaningfully different amounts of the same moderate dough.
- Sitting out is not the risk here — the dough is low in protein, so a knot that has been on the counter a while is a texture and food-safety question, not a histamine one. Bread does not build histamine simply by waiting.
- Garlic is not the driver — if these do not sit well with you, the flour, yeast, and oil are the parts to suspect. Garlic is generally low histamine, and reacting to it is a separate, personal thing.
Lower-histamine alternatives
There is no lower-histamine version of a garlic knot on this menu, so the realistic move is to build around them rather than swap them. At Papa Murphy's, Chicken, Onion Mix, and Zesty Herb Blend are the lower-histamine picks available, and leaning on those for the rest of your order keeps the total lower even if the knots are in the bag.
How to lower the risk
Because Papa Murphy's is a build-to-order counter, the part you actually control is what you pair the knots with rather than what is in them. Nothing is published as removable from these knots, so treat them as fixed and keep the portion modest: taking a couple rather than working through the whole order is the single most useful thing you can do. If you want the rest of the meal to stay gentle, build it on Chicken, Onion Mix, and Zesty Herb Blend, which come in lower than the knots do.
Common questions
Is garlic high in histamine?
No, garlic is generally low in histamine, and it is not what makes these knots moderate. Some people simply do not tolerate garlic, but that is individual intolerance rather than histamine.
Is the yeast in garlic knots a histamine problem?
Baking yeast rates moderate on this index, and in a leavened dough like this it is one of three components pushing the knots into the middle, along with the wheat flour and the soybean oil.
Are garlic knots worse than the rest of a Papa Murphy's order?
They sit at moderate, which is higher than Chicken, Onion Mix, and Zesty Herb Blend, the lower-histamine options on this menu.
Do garlic knots get higher in histamine if they sit out?
Not meaningfully. Histamine needs protein to form from, and this is a plain dough. Leaving them out is a freshness and food-safety issue rather than a histamine one.
This rating comes from Papa Murphy's own published ingredient statement, read on August 10, 2026. Restaurant recipes vary by location and change over time, so always check the current listing: source 1, source 2. How we rate foods →
Papa Murphy's Garlic Knots and Papa Murphy's are trademarks of their respective owners. This page is an independent histamine reference and is not affiliated with, endorsed by, or sponsored by the brand.
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For educational purposes only. Not medical advice. Consult a healthcare professional for personal guidance.
References
- SIGHI Food Compatibility List — SIGHI (2026)
- Histamine and histamine intolerance — Maintz & Novak (2007)
- Histamine Intolerance: The Current State of the Art — Comas-Basté et al. (2020)
- Low-Histamine Diets: Is the Exclusion of Foods Justified by Their Histamine Content? — Sánchez-Pérez et al. (2021)
- Histamine Intolerance: Symptoms, Diagnosis, and Beyond — Jochum (2024)
- Guideline on management of suspected adverse reactions to ingested histamine — Reese et al. (2021)