Is Panera Bread Caramel Pumpkin Slice High in Histamine?

Panera Bread Caramel Pumpkin Slice

Moderate histamine

This caramel pumpkin slice is moderate in histamine, driven by the pumpkin-spiced loaf and its icing.

Food here is usually assembled to order from components that were prepped earlier in the day, so it tends to be fresher than a drive-through and less fresh than cooking at home. Histamine builds up as protein foods sit, so how long the chicken or beef has been in the warmer matters as much as what is in the bowl. Treat the rating above as a starting point.

Gluten Dairy

This is a slice of pumpkin caramel loaf cake topped with pumpkin spice icing.

The pumpkin-spiced loaf — the naturally flavored pumpkin caramel loaf lands at moderate, largely from the warm spice blend woven through it.
The pumpkin spice icing — the icing also sits at moderate, so both the cake and the topping keep this in the middle rather than low.

If you'd like something lower, a plain unspiced bakery item is a calmer pick.

This rating comes from Panera Bread's own published ingredient statement, read on August 23, 2026. Restaurant recipes vary by location and change over time, so always check the current listing: source 1, source 2. How we rate foods →

Panera Bread Caramel Pumpkin Slice and Panera Bread are trademarks of their respective owners. This page is an independent histamine reference and is not affiliated with, endorsed by, or sponsored by the brand.