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Hamburger Helper Cheeseburger Macaroni

High histamine

This cheeseburger macaroni mix is high in histamine, driven by tomato powder and aged cheddar.

Gluten Histamine Liberator

It is pasta with a seasoning blend of tomato powder, cheddar, onion and garlic powder, and MSG.

  • Tomato powder and cheddar — tomato is a classic histamine liberator, and cheddar is an aged cheese where histamine builds up, so each one alone lifts the whole box.

  • Onion and garlic powder — these sit at moderate and add to the picture, while the pasta itself stays milder.

Between the tomato and the aged cheese, there is no easy way to bring this box down.

What's in it

This is a packaged product, so its rating comes from its ingredients. Here is what it is typically made of and where the histamine sits. Tap any whole food for the full detail.

This rating is derived from the product's commonly listed ingredients, which can change over time, so always check the current label. How we rate foods →

Hamburger Helper Cheeseburger Macaroni and Betty Crocker are trademarks of their respective owners. This page is an independent histamine reference and is not affiliated with, endorsed by, or sponsored by the brand.

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Learn more

Foods With High Histamine Levels Why Freshness Matters More Than Food Lists Why Leftovers Can Trigger Histamine Symptoms What Are Histamine Liberators?

For educational purposes only. Not medical advice. Consult a healthcare professional for personal guidance.

References

  1. SIGHI Food Compatibility List — SIGHI (2026)
  2. Histamine and histamine intolerance — Maintz & Novak (2007)
  3. Histamine Intolerance: The Current State of the Art — Comas-Basté et al. (2020)
  4. Low-Histamine Diets: Is the Exclusion of Foods Justified by Their Histamine Content? — Sánchez-Pérez et al. (2021)
  5. Histamine Intolerance: Symptoms, Diagnosis, and Beyond — Jochum (2024)
  6. Guideline on management of suspected adverse reactions to ingested histamine — Reese et al. (2021)