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Iceberg lettuce

Low histamine

One of the most histamine-friendly vegetables — fresh, mild, and well-tolerated by most people with histamine sensitivity.

Iceberg lettuce is low in histamine and doesn't appear to trigger histamine release or block the enzyme that breaks histamine down.

  • Freshness matters — like all leafy greens, histamine can build up once cut leaves start to wilt, so fresher is better

  • Compared to other lettuces — iceberg tends to be even more neutral than darker, more complex greens like romaine or mesclun

Keeping it crisp and fresh in the fridge helps it stay as gentle as possible.

Track your reactions to iceberg lettuce in Histamine Tracker. Log meals and symptoms to spot the patterns that matter for your body.

For educational purposes only. Not medical advice. Consult a healthcare professional for personal guidance.

References

  1. SIGHI Food Compatibility List — SIGHI (2026)
  2. Histamine and histamine intolerance — Maintz & Novak (2007)
  3. Histamine Intolerance: The Current State of the Art — Comas-Basté et al. (2020)
  4. Low-Histamine Diets: Is the Exclusion of Foods Justified by Their Histamine Content? — Sánchez-Pérez et al. (2021)
  5. Histamine Intolerance: Symptoms, Diagnosis, and Beyond — Jochum (2024)
  6. Guideline on management of suspected adverse reactions to ingested histamine — Reese et al. (2021)